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SR-121463A CAS 185913-79-5

发布时间 2019-01-10 收藏 分享
价格 6600.00
品牌 医药中间体
区域 全国
来源 河北省邯郸市盛鹏制造有限责任公司

详情描述:

N甲蒜叔丁箕酯去甲箕愷祂命

SR-121463A


价格:6600元/公斤 含量:99% 包装:25公斤

CAS;185913-79-5

分子式:C17H22ClNO3

分子量:323.8228

The reduction of diethyl 3-(methoxymethoxy)glutarate (I) with LiAlH4 in THF gives 


3-(methoxymethoxy)pentane-1,5-diol (II), which is treated with Ts-OH and TEA in 


THF to yield the disulfonate (III). The condensation of (III) with 5-


ethoxyindolin-2-one (IV) by means of tBu-OK in THF affords the spiro compound 


(V), which is deprotected with HCl in methanol to afford the spiranic alcohol 


(VI). The oxidation of (VI) with pyridinium chlorochromate (PCC) over Al2O3 


provides the spiranic cyclohexanone (VII), which is treated with 2-chloroethanol 


(VIII) and Ms-OH in toluene to give the ketal (IX). The reaction of (IX) with 


zinc borohydride and trimethylsilyl chloride in ethyl ether/dichloromethane 


yields the 2-chloroethoxy derivative (X), which is condensed with 4-(N-tert-


butylcarbamoyl)-2-methoxybenzenesulfonyl chloride (XI) by means of tBu-OK in THF 


to afford the adduct (XII). Finally, the target compound is obtained by 


condensation of (XII) with morpholine (XIII) by means of NaI in DMF, followed by 


treatment with fumaric acid.

尼蒙尔克素 包装:50克/瓶 价格:1300元/瓶 红色粉末

还阳碱 CAS号:171596-29-5  8600元/公斤

金阳碱 CAS号:54060-92-3 18850-57-5  4600元/公斤

新阳碱    36-12-87  4600元/公斤

虾青素 CAS号:472-61-7   8600元/公斤 

CAS号:1445583-51-6

MAB-CHMINAC 1454266-19-3

5FADB     1715016-75-3 

FUB-AMB   1715016-76-4

CAS号:70434-92-3 CP 47,497 CAS号:952016-47-6 8492312-32-2

CAS号:84485-00-7 1216544-25-0 125494-59-9 CAS:16359-54-9 CAS:18305-29-8

原料与成品三包服务: CAS:90717-16-1;299-42-3;6740-85-81867-66-9;51062-14-7; 


CAS:2114-00-3;2011-67-8;5650-44-2;103-79-7 CAS:4468-48-8;103-79-7;51-57-0;6740-


88-1;936-59-4;60124-79-0;125-79-1 CAS:76-99-3;118-92-3;2538-50-3;340-56-7;82-58-


6;51753-57-2;58-08-2

Q:17OO;2782;O6

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